Theory 41/New analysis/Oncology
Gradients Explain Heterogeneity
The claim
Intratumoural metabolic gradients explain more of the variation in drug response than genetic heterogeneity does.
01Mechanism
Drug efficacy depends on local metabolite supply, which varies over tens of micrometres.
02Prediction
Response should map onto gradients.
03Refutation
Response mapping onto genotype would remove the gradient.