Theory 40/New analysis/Structural biology
Ensembles Predict Allostery
The claim
Whether a protein is allosteric is predicted by the width of its conformational ensemble rather than by its ground-state structure.
01Mechanism
Allostery requires the protein to move between states; a rigid protein cannot transmit a signal.
02Prediction
Ensemble width should predict allostery.
03Refutation
Allostery predicted by structure alone would remove the ensemble.