Theory 21/Wound healing/Termination phase
Closure Stops on Contact
The claim
Keratinocyte migration ceases when the ratio of free edge to contact inhibition falls to zero, so closure terminates by contact rather than by signal.
01Mechanism
Migration is contact-inhibited; confluence removes the drive.
02Prediction
Closure should stop at contact regardless of growth factors.
03Refutation
Closure continuing past confluence would remove contact inhibition.