Incoprea Theory
Vol. XXVI · 129

Theory 20/Wound healing/Progression phase

Closure Is Granulation Against Contraction

The claim

How a wound closes is set by the ratio of granulation tissue formation to myofibroblast contraction, so the same wound closes differently in different sites.

01Mechanism

New tissue fills while contraction pulls edges; the ratio determines the mechanism.

02Prediction

Closure mode should track the ratio.

03Refutation

Closure tracking wound size would remove the mechanism balance.