Theory 16/Hours to Days/Pharmacokinetics
Dosing Is Half-Life Against Interval
The claim
Whether a dosing regimen maintains therapeutic levels is set by the ratio of half-life to dosing interval, so the same dose can accumulate or fail depending on that ratio.
01Mechanism
Concentration decays between doses; the ratio determines the trough relative to the peak, and therefore whether the range stays therapeutic.
02Prediction
Trough levels should track the ratio.
03Refutation
Trough tracking dose would remove the half-life.