Theory 18/The rival is the same mechanism at another scale/Pharmacology
Noise or Mean?
The claim
Cellular drug response is predicted by expression noise better than by mean expression.
01The rival explanation
Noise is a by-product of mean level, so a model using the mean captures everything the noise appears to add.
02What would tell them apart
Isogenic populations can be constructed with equal means and different noise.
03Prediction
Response should differ across equal-mean, different-noise populations.
04Refutation
If response is identical at equal mean, the rival wins.