Theory 01/Speed vs Accuracy/Immunity
Fast Responses Are Blunt
The claim
The speed of an immune response trades against its affinity, so a response that arrives quickly is necessarily less specific than one that matures.
01Mechanism
Affinity maturation requires cycles of mutation and selection; accelerating deployment means deploying the early, low-affinity repertoire before it has been refined.
02Prediction
Fast responders should show broader but weaker binding.
03Refutation
Speed and affinity varying independently would remove the trade-off.