Theory 20/Hours to Days/Fever
Fever Timing Is Clearance Against Activation
The claim
The shape of a fever curve is set by the ratio of pyrogen clearance to immune activation time, so the same peak can be reached quickly or slowly with different clinical meaning.
01Mechanism
Pyrogen raises the set point while clearance lowers it; the ratio determines whether the curve is a spike or a plateau.
02Prediction
Curve shape should track the ratio.
03Refutation
Curve tracking peak temperature would remove kinetics.