Theory 69/Timing & Gating/Vaccination
Timing Sets Vaccine Response
The claim
Vaccine immunogenicity is set by the ratio of the interval before exposure to the time needed for the response to mature, not by dose or formulation.
01Mechanism
Protection requires antibody to peak before exposure; a large interval allows maturation, while a short one leaves the response incomplete.
02Prediction
Efficacy should track the interval ratio.
03Refutation
Efficacy independent of interval would remove the timing term.