Theory 70/Timing & Gating/Radiotherapy
Radiosensitivity Is Gated by Phase
The claim
Radiosensitivity is set by the fraction of cells in the sensitive phase at the time of exposure, so fractionation matters more than total dose.
01Mechanism
Damage is repaired efficiently in some phases and poorly in others; redistribution between fractions changes the fraction of cells that are sensitive.
02Prediction
Cell kill should track the phase fraction.
03Refutation
Kill tracking total dose would remove the gating.