Theory 34/Migraine cycle/Onset phase
Onset Is a Susceptibility Threshold
The claim
A migraine attack begins when the ratio of cortical excitability to inhibitory reserve exceeds a threshold, which is why the same trigger affects people differently.
01Mechanism
Susceptibility is a balance; the ratio determines whether a trigger crosses it.
02Prediction
Onset should track the ratio.
03Refutation
Onset tracking trigger strength would remove susceptibility.