Theory 14/Circadian oscillator/Progression phase
Period Is a Network Property
The claim
The free-running period is set by the ratio of transcription to degradation rates in the core loop, not by any single component.
01Mechanism
Period emerges from the delay and the rates; changing either shifts it.
02Prediction
Period should track the rate ratio.
03Refutation
Period tracking one protein's abundance would remove the loop.