Theory 44/Tissue/Tissue remodelling
Remodelling Weighs Two Signals
The claim
Tissue remodelling direction is set by the ratio of mechanical to biochemical signal, so a strong chemical cue can override a moderate mechanical one.
01Mechanism
Cells integrate both inputs; the ratio determines whether matrix is aligned to load or to a chemical gradient.
02Prediction
Remodelling should follow the dominant signal.
03Refutation
Remodelling tracking one signal would remove the integration.