Theory 38/Tissue/Wound contraction
Contraction Needs a Soft Matrix
The claim
Wound contraction is set by the ratio of myofibroblast force to matrix stiffness, so a stiff scar contracts less despite more force.
01Mechanism
Contraction requires shortening; a matrix that resists deformation converts force into tension without movement.
02Prediction
Contraction should fall as stiffness rises.
03Refutation
Contraction tracking force alone would remove stiffness.