Theory 27/Cellular/Autophagy
Flux Is Vesicle Against Capacity
The claim
Autophagic flux is set by the ratio of autophagosome production to lysosomal degradation capacity, so measuring autophagosomes alone misreads flux in both directions.
01Mechanism
Substrate accumulates when production outpaces degradation; a high vesicle count can mean fast production or slow clearance.
02Prediction
Flux should track the ratio.
03Refutation
Flux tracking vesicle count would remove capacity.