Theory 04/Peclet Number/Tumour penetration
Drug Penetration Is a Peclet Problem
The claim
Penetration of a drug into a solid tumour is set by the interstitial Peclet number, so a drug with high potency but poor diffusion reaches less tissue than a weaker one that moves well.
01Mechanism
Convection and diffusion compete in the interstitium; when convection dominates, drug is carried past rather than into the tissue.
02Prediction
Penetration depth should track the Peclet number.
03Refutation
Penetration tracking potency would remove the transport term.