Theory 24/Weeks to Months/Vaccination
Response Is Maturation Against Exposure
The claim
Vaccine efficacy is set by the ratio of germinal centre maturation time to the interval before exposure, so a compressed schedule leaves affinity immature.
01Mechanism
Antibody affinity rises over weeks in the germinal centre; if exposure arrives before maturation, the response is lower affinity and less durable.
02Prediction
Efficacy should track the ratio.
03Refutation
Efficacy tracking dose would remove the maturation term.