Theory 50/Precision & Information/Genomics
Coverage Sets Detection
The claim
The ability to detect a variant is set by the ratio of sequencing depth to the variant allele fraction, not by depth alone.
01Mechanism
A low-fraction variant requires enough reads to distinguish it from error; depth relative to fraction sets the confidence.
02Prediction
Detection should track the ratio.
03Refutation
Detection tracking depth alone would remove the fraction term.