Theory 48/Immunoengineering
Depot Effect Is a Persistence Ratio
The claim
The depot effect of a vaccine formulation is set by the ratio of particle persistence to antigen release rate rather than by total antigen dose.
01The mechanism
Sustained immune stimulation requires antigen to be available over time; a depot that releases faster than it persists produces a burst rather than a response.
02Predictions
- P1Response should track the ratio.
- P2Dose alone should mispredict.
03Refutation
Response tracking dose would remove the kinetics.