Theory 46/Tissue Engineering
There Is a Stiffness Optimum
The claim
Matrix stiffness for tissue growth peaks at an optimum set by the ratio of cell traction to matrix modulus, rather than increasing monotonically.
01The mechanism
Too soft and cells cannot generate tension to organise matrix; too stiff and they cannot remodel it, so an intermediate ratio maximises deposition.
02Predictions
- P1Deposition should peak at a modulus.
- P2Stiffer matrices should not always be better.
03Refutation
Monotonic improvement with stiffness would remove the optimum.